النشر العلمي

  • Toxicity of the Aqueous extract of Colocynth Citrullus colocynthis (L.) Schrad. on laboratory rat Rattus norvigicus

Abstract

This study aimed at investigating the acute toxicity of the aqueous-extract of colocynth (Hanzal) Citrullus colocynthis (L.) Schrad, using albino laboratory rats Rattus norvigicus as laboratory experimental animals. Five dosage levels were selected according to preliminary screening tests. These were 90, 180, 225, 270 and 315 mg. They were administered orally through intubation to each group of albino rats. The treated rats were observed for 24 hr for acute toxicity symptoms. Death almost occurred between 1 – 18 hrs after the treatment. Corrected mortalities were 0, 33.3, 50, 66.7 and 100 corresponding to the above mentioned dosage levels respectively. The mean oral LD50 was determined through probit analysis, it was found to be 2402 mg/kg body weight. Symptoms of toxicity were severe anorexia, diarrhoea, difficulty in breathing, inability to stand upright, collapse,  muscles atrophy and death.

Abbreviations: Hf.Aq.Extr. : Hanzal fruit Aqeous extract

Key words: Colocynth (Citrullus colocynthis)-  albino rats- intubation- probit analysis- anaroxia – acute toxicity

published in جامعة السودان للعلوم البيطرية والزراعية

  • Hypoglycemic and toxic effects of saponins from the fruit of bitter apple [Citrullus colocynthis (L.) Schrad] on the internal organs of Norway rat [Rattus norvegicus (Berkenhout)]

 

Nowadays ,natural products  receive  attention  to  research  centers because  of  their  special  importance  in  safety  of communities.  The  curative  properties  of  these  plants are  mainly  due  to  the  presence  of  various  complex chemical substances of different composition  which occur as  secondary  metabolites.  The main objectives of this study were to evaluate saponins toxic effects as reflected in the  histopathological changes in the internal organs of Norway rats and to  study the hypoglycemic effects induced by the same group. Powdered dried fruit parts (rinds, pulps and seeds) of bitter apple were screened for detection of saponins, glycosides, terpenes, anthraquinones, flavonoids, tannins, alkaloids, coumarins, cardiac glycosides, cyanogenic glycosides and cucurbitacins. The results of the qualitative analysis and phytochemical screening profiles indicated that, most of the natural products tested for were present in the plant material, except cyanogenic glycosides. Crude saponins were extracted from the rind and their acute toxicity was determined on Norway rats. Five dosage levels (60, 70, 80, 90 and 100 mgs saponins/rat) were administered intraperitoneally to each batch of albino rats (4 rats/ batch). The histological changes in the liver exhibited prominent nucleolus, open chromatin, congestion of central veins and liver sinusoids. The kidney showed signs of reduced renal tubules and lining of epithelial cells. The stomach and digestive system showed mucosal edema, open chromatin, prominent nucleolus and structural necrosis. Percentages reduction in glucose level  in treated rats and the control after six hours were 42%, 55.4%, 60%, 62.5%, 69.3 and 0.10 % , following the same order. There was a considerable dose-dependent decrease in the mean concentration of glucose in the plasma of the treated rats.

published in مجلة جامعة الجزيرة للعلوم الزراعية

  • Acute toxicity of saponins from the fruit of bitter apple Citrullus colocynthis (L.) Schrad, on the Norway rat, Rattus norvegicus (Berkenhout)

ABSTRACT                            

 

       Citrullus colocynthis (L.) Schrad (CCT) is an important medicinal plant belonging to the family Cucurbitaceae. It is a well-recognized plant in the traditional medicine and used in rural areas as a purgative, antidiabetic and insecticide. The objective of this study was to evaluate saponins acute toxicity. Crude saponins were extracted from the rind and their acute toxicity was determined on Norway rat Rattus norvegicus (Berkenhout). Five dosage levels (60, 70, 80, 90 and 100 mgs saponins/rat) were selected following a pilot study and administered intraperitoneally (I.P.) to each batch of albino rats (4 rats/ batch). The treated rats were observed for 96 hr for acute toxicity symptoms. Death occurred between 1 – 4 days post- treatment. The corrected mortalities were 0, 25, 50, 75 and 100%, respectively. The LC50 was 79.43 mg / rat. Symptoms and behavioural changes during the observation period were anorexia, abnormal gait, twitches, blepharoptosis, reduced activity and bleeding. Severe diarrhoea was the most serious symptom. The study has identified CCT, viz. its saponins content, as a promising plant with acute and broad rodenticidal activity.

 

published in مجلة جامعة الجزيرة للعلوم الزراعية

  • Controlling Home Devices for Handicapped People via Voice Command Techniques

Man, has five senses representing natural windows
of communication between him and the outside world. Talking is
the best means of communication existing. Speech recognition
can be applied in computer devices to control the useful software
to facilitate people in their life. Handicapped people suffer the
difficulty of movement inside their home to spend some basic
needs and necessities, usually need another person to help them
in that. This assistance is achieved through the design of a special
system for handicapped people to control home devices by using
voice commands. This paper shows a way to control home devices
with computer through interface circuit based on the
Microcontroller and Universal Serial Bus interface. The design
and implementation processes were carried out in two parts
hardware and software. The requirements of hardware design
and implementation are wireless microphone, personal computer,
home devices and interface circuit connected between personal
computer and homes devices via USB cable. Interface circuit was
designed, simulated and tested using Proteus and MikroC.
Software system was designed and implemented using Microsoft
Visual Basic programming language and Microsoft Speech
Recognition engine. To use a system, the person gives a voice
command to the computer via wireless microphone; the
computer card converts voice command into a digital format.
The acoustical software model breaks the word into phonemes.
The software language model compares the phonemes to
commands, if it is, the programming language translates the
command to digital value, and after that transfer the digital value
to interface circuit to control the specified home device. The
research recommends using this system to control home devices
remotely through the internet or smart mobile phone.
 

published in ICCNEEE 2015, IEEE Sudan Subsection

  •  RFID Approach in VANET Environment

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published in ICOM13 Kuwala Lampour

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